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A STUDY ON THE GENETIC DISORDER OF AZF MICRODELETIONS ON THE Y CHROMOSOME OF INFERTILE MEN
Fairy Priyank Salecha1, Dr. Nirmal Sharma2
Abstract:
"Azoospermia factor locus" Gonadotropins genes are located on Yq11.23 in intervals V and VI (AZF). Male infertility associated with fertility problems may result from these gene losses. The occurrence of Y chromosomes developmental abnormalities in male infertiles with oligozoospermia or oligozoospermia was investigated in this research. Sequence-tagged site (STS) staple sets were used in pcr Technique in the current investigation to identify Y chromosomal outcome is possible. 61 infertile guys were tested in the current investigation for molecular AZF. The other males had 46,XY, whereas one fertile man had 46,XX. 48 people had secondary hypogonadism, whereas 13 had oligozoospermia. Two of 60 (3.3%) guys with appropriate genetic makeups who were diagnosed barren also had outcome is possible in AZFa, AZFb, &AZFc (DAZ gene) areas, and 46,XX males had SRY translocations. Present study findings indicate genetic screening before assisted reproductive therapy for infertile men.
