• Effectiveness of Multi-domain Interventions on Improving Intrinsic Capacity in Older Adults: A Systematic Review

  DOI:DOI:18.A003.aarf.J14I01.010567

Hong-Miao Lin, RN

Abstract: Background and Objective: This systematic review evaluates the effectiveness of multi-domain interventions in enhancing the intrinsic capacity (IC) of older adults aged 65 and above. Methods: Following the PRISMA 2020 guidelines, a systematic search was conducted across six electronic databases for randomized controlled trials published between 2020 and 2025. Nine studies involving 4,723 participants were included. Results: The findings indicate that multi-domain interventions significantly improved overall IC for older adults. Physical activity (aerobic and resistance exercise) enhanced locomotor capacity, including muscle strength, balance, and gait. Cognitive training improved executive function and attention. Nutritional supplementation (e.g., high protein, Omega-3), combined with exercise, effectively increased muscle mass and reduced fall risks. Additionally, health education and empowerment strategies bolstered health literacy and exercise motivation. Conclusion: Intervention efficacy depends on participant adherence, program complexity, and baseline IC scores. Future research should standardize IC assessment tools and integrate community-based empowerment strategies to ensure sustainable outcomes.